公开(公告)号：US09265730B2

公开(公告)日：2016-02-23

申请号：US14194050

申请日：2014-02-28

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Muneo Nonomura ,  Hiroki Ito ,  Hideo Hashimoto ,  Tadashi Urai

IPC: A61K9/16 ,  A61K9/24 ,  A61K9/48 ,  A61K31/4439 ,  A61K47/02

CPC classification number: A61K9/1676 ,  A61K9/209 ,  A61K9/4808 ,  A61K31/4439 ,  A61K47/02

Abstract: It is intended to provide a process for producing unstable amorphous benzimidazole compounds having a proton pump inhibitor function, and stable solid preparations for medicinal use containing these compounds which are produced by blending such an amorphous benzimidazole compound with a nontoxic base such as a basic inorganic salt, forming an intermediate coating layer on the layer containing the active ingredient and further forming an enteric coating layer or a release-controlling coating layer.