公开(公告)号：US10849902B2

公开(公告)日：2020-12-01

申请号：US16065362

申请日：2016-12-21

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Takahisa Matsuda ,  Takashi Motoyaji ,  Shuji Kitamura ,  Masato Yoshida

IPC: A61K31/517 ,  A61K31/519 ,  A61P9/04

Abstract: The present invention provides a medicament for preventing or treating heart failure. More specifically, the present invention provides a medicament for preventing or treating heart failure, comprising a compound selected from the group consisting of (5R)—N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, (5R)—N-[1-ethyl-1-(4-methoxyphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, (5R)—N-[1-ethyl-1-(4-ethylphenyl)propyl]-5-(2-fluorophenyl)-2,7,7-trimethyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and salts thereof.

公开(公告)号：US10786506B2

公开(公告)日：2020-09-29

申请号：US16065362

申请日：2016-12-21

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Takahisa Matsuda ,  Takashi Motoyaji ,  Shuji Kitamura ,  Masato Yoshida

IPC: A61K31/517 ,  A61K31/519 ,  A61P9/04

Abstract: The present invention provides a medicament for preventing or treating heart failure. More specifically, the present invention provides a medicament for preventing or treating heart failure, comprising a compound selected from the group consisting of (5R)—N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, (5R)—N-[1-ethyl-1-(4-methoxyphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, (5R)—N-[1-ethyl-1-(4-ethylphenyl)propyl]-5-(2-fluorophenyl)-2,7,7-trimethyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and salts thereof.

公开(公告)号：US20200054637A1

公开(公告)日：2020-02-20

申请号：US16065362

申请日：2016-12-21

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Takahisa Matsuda ,  Takashi Motoyaji ,  Shuji Kitamura ,  Masato Yoshida

IPC: A61K31/519 ,  A61P9/04

Abstract: The present invention provides a medicament for preventing or treating heart failure. More specifically, the present invention provides a medicament for preventing or treating heart failure, comprising a compound selected from the group consisting of (5R)—N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, (5R)—N-[1-ethyl-1-(4-methoxyphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, (5R)—N-[1-ethyl-1-(4-ethylphenyl)propyl]-5-(2-fluorophenyl)-2,7,7-trimethyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and salts thereof.