公开(公告)号：US20140256693A1

公开(公告)日：2014-09-11

申请号：US14173388

申请日：2014-02-05

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Masuo Yamaoka ,  Takahito Hara

IPC: C07D487/04 ,  A61K45/06 ,  A61K31/4188

CPC classification number: C07D487/04 ,  A61K31/4188 ,  A61K45/06

Abstract: The present invention mainly aims to provide a drug for the prophylaxis or treatment of androgen-independent prostate cancer, which is highly useful as a pharmaceutical agent. The present invention provides a drug for the prophylaxis or treatment of androgen-independent prostate cancer, containing a steroid C17,20 lyase inhibitor, particularly, a compound represented by the formula (I): wherein n is an integer of 1 to 3, and Ar is an aromatic ring optionally having substituent(s), or a salt thereof or a prodrug thereof.

Abstract translation: 本发明的目的在于提供一种用于预防或治疗雄激素依赖性前列腺癌的药物，其作为药剂是非常有用的。 本发明提供一种用于预防或治疗雄激素依赖性前列腺癌的药物，其含有类固醇C17,20裂解酶抑制剂，特别是由式（I）表示的化合物：其中n为1〜3的整数， Ar是任选具有取代基的芳香环，或其盐或其前药。