公开(公告)号：US20170008885A1

公开(公告)日：2017-01-12

申请号：US15103900

申请日：2014-12-12

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Summon KOUL ,  Suresh KURHADE ,  Sandeep BHOSALE ,  Keshav NAIK ,  Videsh SALUNKHE ,  Yogesh MUNOT ,  Debnath BHUNIYA

IPC: C07D471/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: The present invention provides a heterocyclic compound having a TLR7, TLR9, TLR7/8, TLR7/9 or TLR7/8/9 inhibitory action, which is useful as an agent for the prophylaxis or treatment of autoimmune diseases, inflammatory diseases and the like, in particular, systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, psoriasis, inflammatory bowel disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.

Abstract translation: 本发明提供具有TLR7，TLR9，TLR7 / 8，TLR7 / 9或TLR7 / 8/9抑制作用的杂环化合物，其可用作预防或治疗自身免疫性疾病，炎性疾病等的药剂， 特别是系统性红斑狼疮，干燥综合征，类风湿性关节炎，牛皮癣，炎症性肠病等。 本发明是由式（1）表示的化合物：其中每个符号如说明书中所述或其盐。