专利检索 ap:("TAKEDA PHARMACEUTICAL COMPANY LIMITED") AND inv:"Yogesh Waman" 第 1 页

1.

发明授权
1-Substituted 1,2,3,4-tetrahydro-1,7-naphthyridin-8-amine derivatives and their use as EP4 receptor antagonists 有权

公开(公告)号：US10745397B2

公开(公告)日：2020-08-18

申请号：US15746828

申请日：2016-07-26

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Dinesh Barawkar , Anil M Deshpande , Santosh Patil , Yogesh Waman , Anil Panmand , Dilip Jadhav , Bheemashankar Kulkarni

IPC分类号： C07D498/04 , C07D471/04 , C07D513/04 , A61P19/02

摘要： The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof has an EP4 receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of EP4 receptor associated diseases (e.g., rheumatoid arthritis, aortic aneurysm (e.g. abdominal aortic aneurysm, thoracic aortic aneurysm, thoracoabdominal aortic aneurysm etc.), endometriosis, ankylosing spondylitis, inflammatory breast cancer etc.) and the like.