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1.发明公开公开(公告)号：US20230173241A1
公开(公告)日：2023-06-08
申请号：US17927445
申请日：2021-06-04
发明人： Yunhua GAO , Xiaoyu ZHAO , Suohui ZHANG
CPC分类号： A61M37/0015 , C08L39/06 , C08L1/02 , A61M2037/0046 , C08L2201/06 , C08L2203/02
摘要： Disclosed are a heat-resistant implantable polymer microneedle and a preparation method therefor and an application thereof. The microneedle comprises a needle tip, a needle body, and a base, wherein the needle tip comprises a homogeneous system formed by mixing a biodegradable macromolecular material which has a glass transition temperature of 35-65° C. and is difficultly soluble in water and a macromolecular material having a glass transition temperature higher than that of the biodegradable macromolecular material. The microneedle has good heat resistance and puncture property.
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公开(公告)号：US20230310822A1
公开(公告)日：2023-10-05
申请号：US18024585
申请日：2021-09-07
发明人： Yunhua GAO , Zequan ZHOU , Suohui ZHANG
CPC分类号： A61M37/0015 , A61K9/7023 , B05D7/586 , A61M2037/0053 , B05D2520/00 , B05D2320/00
摘要： The present application discloses a coated microneedle with a multilayer structure, including a base, a needle tip on the base, and a functional coating. The functional coating includes a content including a water-soluble polymer material and an active ingredient, and a sustained-release layer wrapping the content. The sustained-release layer covers the needle tip. The coated microneedle can prevent a drug-containing matrix from being quickly dissolved and dispersed, prevent the active ingredient from exuding along with tissues at an action site, and increase the drug intake. The present application further discloses a method for preparing the coated microneedle and a microneedle patch including the coated microneedle.
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