公开(公告)号：US20140045809A1

公开(公告)日：2014-02-13

申请号：US14016262

申请日：2013-09-03

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.

Inventor： Moussa B.H. YOUDIM ,  Silvia MANDEL ,  Tamar AMIT ,  Orit BAR-AM ,  Lana KUPERSHMIDT ,  Zeev GROSS ,  Atif MAHAMMED ,  Irena SALTSMAN ,  Zoya OKUN

IPC: A61K31/555

CPC classification number: A61K31/555 ,  A61K31/00 ,  A61K31/409 ,  C07D487/22

Abstract: Transition metal complexes of amphiphilic corroles, optical isomers and pharmaceutically acceptable salts thereof are useful for neuroprotection and neurorescue, particularly for treatment of diabetes and neurodegenerative diseases. The amphiphilic corrole is preferably a 5,10,15-tris-aryl- or 5,10,15-tris-CF3-corrole, and said transition metal complex more preferably has the formula I defined in the specification. Also provided are propargyl-containing corroles carrying one or more radicals substituted by a propargylamino group or one or more nitrogen-containing heteroaryl radicals substituted by propargyl at the ring N atom.

Abstract translation: 两亲性腐蚀物的过渡金属络合物，光学异构体和其药学上可接受的盐可用于神经保护和神经保护，特别是用于治疗糖尿病和神经变性疾病。 两亲性糠醛优选为5,10,15-三 - 芳基 - 或5,10,15-三 - 三氟甲基 - 三氟甲基 - 糠醛，所述过渡金属配合物更优选具有本说明书中定义的式Ⅰ。 还提供了携带一个或多个被炔丙基氨基取代的基团或一个或多个在环N原子上被炔丙基取代的含氮杂芳基的炔基的冠状物。