公开(公告)号：US20240075017A1

公开(公告)日：2024-03-07

申请号：US18280325

申请日：2022-03-08

Applicant: TECHNISCHE UNIVERSITÄT MÜNCHEN

Inventor： Andreas PICHLMAIR ,  Valter BERGANT ,  Vincent GRASS

IPC: A61K31/437 ,  A61K31/136 ,  A61K31/4745 ,  A61K31/573 ,  A61K31/706 ,  A61P31/14

CPC classification number: A61K31/437 ,  A61K31/136 ,  A61K31/4745 ,  A61K31/573 ,  A61K31/706 ,  A61P31/14

Abstract: The invention refers to an inhibitor of at least one S-adenosylmethionine (SAM) cycle enzyme for use in preventing or treating coronavirus disease 2019 (COVID-19) in a subject, or for use in preventing or treating of infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in a subject, wherein the at least one SAM cycle enzyme is selected from the group consisting of methionine adenosyltransferase, betaine-homocysteine methyltransferase, methionine synthase, methionine synthase reductase and S-adenosylhomocys.