公开(公告)号：US20190388360A1

公开(公告)日：2019-12-26

申请号：US16481579

申请日：2018-01-29

申请人： TEIKOKU SEIYAKU CO., LTD.

发明人： Antonio NARDI ,  Klaus SCHIENE ,  Thomas CHRISTOPH ,  Sebastian WACHTEN ,  Irmgard BÖSL ,  Andreas SCHOLZ ,  Ingo FRIEDRICH ,  Sebastian ULLRICH ,  Simone KÖNIG

IPC分类号： A61K9/70 ,  A61K31/167 ,  A61K31/196 ,  A61K9/00

摘要： The invention relates to a pharmaceutical patch comprising a Lidocaine constituent and a Diclofenac constituent, wherein the relative weight content ratio of the Lidocaine constituent to the Diclofenac constituent is within the range of from about 7:1 to about 4:1, based on the equivalent weight of the non-salt form of Lidocaine and of Diclofenac, for use in the local treatment or prevention of pain, wherein the pain is neuropathic pain or wherein the pain has a neuropathic pain component. The pharmaceutical composition is suitable for topical administration and local pharmacological action via delivery of Lidocaine and Diclofenac into the skin and possibly also through and to other deeper tissues such as the synovial fluid without significant systemic exposure.