公开(公告)号：US20170016066A1

公开(公告)日：2017-01-19

申请号：US15115807

申请日：2015-01-30

Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Arthur M. FELDMAN ,  Douglas G. TILLEY ,  Weizhong ZHU ,  Kamel KHALILI ,  Walter J. KOCH

IPC: C12Q1/68 ,  G01N33/68

CPC classification number: C12Q1/6883 ,  A61K48/00 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6887 ,  G01N33/6893 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2800/325 ,  G01N2800/50

Abstract: Compositions are directed to BCL2-associated athanogene 3 (BAG3) molecules and agents which modulate expression of BAG3 molecules. Pharmaceutical composition for administration to patients, for example, patients with heart failure, comprise one or more BAG3 molecules or agents which modulate expression of BAG3. Methods of treatment and identifying candidate therapeutic agents are also provided.

Abstract translation: 组合物针对BCL2相关的athanogene 3（BAG3）分子和调节BAG3分子表达的试剂。 用于给予患者的药物组合物，例如患有心力衰竭的患者，包含调节BAG3表达的一种或多种BAG3分子或试剂。 还提供了治疗和鉴定候选治疗剂的方法。