公开(公告)号：US20230064530A1

公开(公告)日：2023-03-02

申请号：US17816345

申请日：2022-07-29

申请人： TEMPUS LABS, INC.

发明人： Ramit Bharanikumar ,  Karl Beutner ,  Jason Perera

IPC分类号： G16B20/00 ,  G16B40/20 ,  G06N20/00

摘要： Processes are provided for identifying somatic variants in a human leukocyte antigen (HLA) gene in a subject using analysis of next generation sequencing (NGS) data. The processes include aligning HLA sequence read data for normal samples and the HLA sequence data for a tumor sample to a patient specific HLA reference genome and performing a variant calling process on filtered aligned read data and determining somatic variants of the HLA class. A report may be generated of somatic variants of the HLA gene annotated for functional effect.