专利检索 ap:("TENACIA BIOTECHNOLOGY (HONG KONG) CO., LIMITED") AND inv:"M. Amin Khan" 第 1 页

1.

发明公开
METHODS OF TREATING PAINFUL DIABETIC PERIPHERAL NEUROPATHY 审中-公开

公开(公告)号：US20240352024A1

公开(公告)日：2024-10-24

申请号：US18650142

申请日：2024-04-30

申请人： TENACIA BIOTECHNOLOGY (HONG KONG) CO., LIMITED

发明人： Torsten M. Madsen , M. Amin Khan , Mohsen Arghavani , Phil Bauer , Eduardo Mar

IPC分类号： C07D487/10 , A61K9/00 , A61K9/20 , A61K9/48 , A61P25/02

CPC分类号： C07D487/10 , A61K9/0053 , A61K9/2013 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K9/4866 , A61P25/02 , C07B2200/13

摘要： Provided herein are methods of treating painful diabetic peripheral neuropathy, such as advanced painful DPN, in a patient by administering to the patient an effective amount of NYX-2925 or a pharmaceutically acceptable salt thereof. Also provided are crystalline forms of 3-hydroxy-2-(5-isobutyryl-1-oxo-2,5-diazaspiro [3,4] octan-2-yl) butanamide.

2.

发明授权
Spiro-lactam NMDA modulators and methods of using same 有权

公开(公告)号：US12084444B2

公开(公告)日：2024-09-10

申请号：US17831547

申请日：2022-06-03

申请人： Tenacia Biotechnology (Hong Kong) Co., Limited

发明人： M. Amin Khan

IPC分类号： C07D471/10 , A61K9/00 , A61P25/02 , A61P25/06 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , C07D487/10

CPC分类号： C07D471/10 , A61K9/0019 , A61P25/02 , A61P25/06 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , C07D487/10

摘要： Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

3.

发明授权
Methods of treating painful diabetic peripheral neuropathy 有权

公开(公告)号：US12012413B2

公开(公告)日：2024-06-18

申请号：US17094584

申请日：2020-11-10

申请人： Tenacia Biotechnology (Hong Kong) Co., Limited

发明人： M. Amin Khan , Mohsen Arghavani , Phil Bauer , Eduardo Mar

IPC分类号： C07D487/10 , A61K9/00 , A61K9/20 , A61K9/48 , A61P25/02

CPC分类号： C07D487/10 , A61K9/0053 , A61K9/2013 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K9/4866 , A61P25/02 , C07B2200/13

摘要： Provided herein are methods of treating painful diabetic peripheral neuropathy, such as advanced painful DPN, in a patient by administering to the patient an effective amount of NYX-2925 or a pharmaceutically acceptable salt thereof. Also provided are crystalline forms of 3-hydroxy-2-(5-isobutyryl-1-oxo-2,5-diazaspiro[3,4]octan-2-yl)butanamide.