公开(公告)号：US20180353489A1

公开(公告)日：2018-12-13

申请号：US16108146

申请日：2018-08-22

申请人： TENNOR THERAPEUTICS (SUZHOU) LIMITED

发明人： Zhenkun Ma ,  Gregory Robertson ,  Xiaomei Wang

IPC分类号： A61K31/4375 ,  A61P31/04 ,  A61K38/12

CPC分类号： A61K31/4375 ,  A61K31/4545 ,  A61K38/12 ,  A61P31/04 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/483

摘要： Provide herein is an antibacterial pharmaceutical combination for treating Gram negative bacterial infections, including a compound TNP-2092 and a cell membrane permeabilizer. Also provided herein is a method for treating Gram-negative bacteria infections in a subject, which includes administrating to the subject the antibacterial pharmaceutical combination.

公开(公告)号：US12005050B2

公开(公告)日：2024-06-11

申请号：US18363006

申请日：2023-08-01

申请人： TENNOR THERAPEUTICS (SUZHOU) LIMITED

发明人： Zhenkun Ma ,  Guozhu Geng ,  Jing Chen ,  Yu Liu ,  Xiangyi Xu ,  Changlin Ai ,  Junlei Zhang ,  Ting Song ,  Shuangshuang Zhao

IPC分类号： A61K31/439 ,  A61K9/28 ,  A61K9/48 ,  A61K31/43 ,  A61K31/4439 ,  A61P31/04

CPC分类号： A61K31/439 ,  A61K9/28 ,  A61K9/48 ,  A61K31/43 ,  A61K31/4439 ,  A61P31/04

摘要： The present disclosure provides methods, drug combinations and kits for treating, ameliorating, reversing and/or preventing a Helicobacter pylori (H. pylori) infection in a patient in need thereof.