专利检索 ap:("TEXAS BIOMEDICAL RESEARCH INSTITUTE") AND inv:"Marcel M. Daadi" 第 1 页

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发明申请
DOPAMINE D3 RECEPTOR LIGANDS FOR TREATMENT OF DYSKINESIA 有权

公开(公告)号：US20220409602A1

公开(公告)日：2022-12-29

申请号：US17840563

申请日：2022-06-14

申请人： TEXAS BIOMEDICAL RESEARCH INSTITUTE

发明人： Marcel M. Daadi

IPC分类号： A61K31/4535 , A61P25/14

摘要： Provided here are arylpiperazine pharmacophore compositions that mitigate levodopa-induced dyskinesia and significantly improve Parkinson's disease-like symptoms. These dopamine D3 receptor ligands have high affinity and selectivity, are orally active, and have desirable drug-like properties.