专利检索 ap:("THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND" OR "DUQUESNE UNIVERSITY OF THE HOLY GHOST") AND inv:"Van T. Hoang" 第 1 页

1.

发明授权
Anthranilic amides and the use thereof 有权

公开(公告)号：US11465978B2

公开(公告)日：2022-10-11

申请号：US15021592

申请日：2014-09-11

申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , DUQUESNE UNIVERSITY OF THE HOLY GHOST

发明人： Suravi Chakrabarty , Patrick T. Flaherty , Darlene Monlish , Jane E. Cavanaugh , Matthew E. Burow , Steven Elliott , Van T. Hoang

IPC分类号： C07D295/192 , C07D295/16 , C07C229/58 , C07C237/30 , C07C237/32 , C07C237/34 , C07C237/36

摘要： Disclosed are anthranilic amide derivatives having the formula. Compositions are disclosed that include the anthranilic amide derivatives and the use of the anthranilic amide derivatives for the manufacture of a medicament. Further disclosed are methods of inhibiting or treating cancer, inhibiting or reversing an epithelial to mesenchymal cellular transition, and/or inhibiting MEK1/2 and/or MEK 5 enzymatic activity in a subject by administering to the subject an effective amount of a disclosed anthranilic amide derivative.