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    NOVEL BIOMARKER FOR PREDICTING SENSITIVITY TO EGFR-TARGETING AGENT, AND USE THEREOF
    1.
    发明申请
    NOVEL BIOMARKER FOR PREDICTING SENSITIVITY TO EGFR-TARGETING AGENT, AND USE THEREOF 审中-公开

    公开(公告)号：US20190127802A1

    公开(公告)日：2019-05-02

    申请号：US15329942

    申请日：2015-07-29

    Applicant: THE ASAN FOUNDATION

    Inventor： Tae Won Kim ,  Dong Hoon Jin ,  Seung Woo Hong ,  Jai Hee Moon ,  Jae Sik Shin ,  Seung Mi Kim ,  Dae Hee Lee ,  Eun Young Lee ,  Seul Lee ,  Yong Sang Hong

    IPC: C12Q1/6886 ,  A61P35/00 ,  A61P43/00

    Abstract: The present disclosure relates to a new biomarker for predicting susceptibility to an EGFR-targeted agent and a use thereof, and more particularly, provides a biomarker for predicting susceptibility to an EGFR (Epidermal Growth Factor Receptor)-targeted agent, comprising a RON (Recepteur d'Origine Nantais) gene; a composition for predicting susceptibility to the EGFR-targeted agent, comprising an agent which measures a gene expression level of the biomarker; or an expression or activity level of a protein thereof; a composition for enhancing the susceptibility to the EGFR-targeted agent, comprising an inhibitor of the expression of the gene or the expression or activity of the protein of the gene as active ingredients; a kit for predicting the susceptibility to the EGFR-targeted agent, comprising the composition; and a method for predicting the susceptibility to the EGFR-targeted agent. According to the present disclosure, since an effect of predicting the susceptibility to the EGFR-targeted agent is excellent in a colon cancer, the present disclosure may be useful in the treatment of the colon cancer.

    Biomarker for predicting sensitivity to EGFR-targeting agent, and use thereof
    3.
    发明授权
    Biomarker for predicting sensitivity to EGFR-targeting agent, and use thereof 有权

    公开(公告)号：US11008622B2

    公开(公告)日：2021-05-18

    申请号：US15329942

    申请日：2015-07-29

    Applicant: THE ASAN FOUNDATION

    Inventor： Tae Won Kim ,  Dong Hoon Jin ,  Seung Woo Hong ,  Jai Hee Moon ,  Jae Sik Shin ,  Seung Mi Kim ,  Dae Hee Lee ,  Eun Young Lee ,  Seul Lee ,  Yong Sang Hong

    IPC: C12Q1/6886 ,  C12Q1/68 ,  A61P43/00 ,  A61P35/00

    Abstract: The present disclosure relates to a new biomarker for predicting susceptibility to an EGFR-targeted agent and a use thereof, and more particularly, provides a biomarker for predicting susceptibility to an EGFR (Epidermal Growth Factor Receptor)-targeted agent, comprising a RON (Recepteur d'Origine Nantais) gene; a composition for predicting susceptibility to the EGFR-targeted agent, comprising an agent which measures a gene expression level of the biomarker; or an expression or activity level of a protein thereof; a composition for enhancing the susceptibility to the EGFR-targeted agent, comprising an inhibitor of the expression of the gene or the expression or activity of the protein of the gene as active ingredients; a kit for predicting the susceptibility to the EGFR-targeted agent, comprising the composition; and a method for predicting the susceptibility to the EGFR-targeted agent. According to the present disclosure, since an effect of predicting the susceptibility to the EGFR-targeted agent is excellent in a colon cancer, the present disclosure may be useful in the treatment of the colon cancer.

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