公开(公告)号：US20160040168A1

公开(公告)日：2016-02-11

申请号：US14779874

申请日：2014-03-27

申请人： THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

发明人： Tae Won Kim ,  Dong Hoon Jin ,  Seung Woo Hong ,  Jai Hee MOON ,  Jae Sik Shin ,  Jin Sun Kim ,  Kyung Ah Jung ,  Jung Shin Lee ,  Eun Kyung Choi ,  Jae Lyun Lee ,  Yong Sang Hong ,  Kyu Pyo Kim ,  Ky Youb Nam ,  Bong Cheol Kim

IPC分类号： C12N15/113 ,  A23L1/30 ,  G01N33/50 ,  A61K31/4245 ,  C12Q1/68

CPC分类号： C12N15/1137 ,  A23L33/13 ,  A23V2002/00 ,  A61K31/4245 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/122 ,  C12N2310/14 ,  C12N2310/531 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011

摘要： The present invention relates to a composition for treatment or metastasis suppression of cancers which includes a p34 expression inhibitor or activity inhibitor as an active ingredient. According to the present invention, the p34 protein knock-down causes monoubiquitination of PTEN and accordingly nuclear localization of PTEN is induced, as a result, an Akt pathway which is related to survival, proliferation, invasive properties and metastatic properties of tumors is inhibited, and thus there is an effect of significantly reducing clonogenic potential and tumor forming potential of various cancer cells which simultaneously express PTEN and NEDD4-1. Consequently, the p34 gene expression inhibitor or p34 protein activity inhibitor according to the present invention can be effectively used as a treatment agent or a metastasis suppression agent for cancers.

摘要翻译： 本发明涉及包含p34表达抑制剂或活性抑制剂作为活性成分的癌症治疗或转移抑制组合物。 根据本发明，p34蛋白敲低引起PTEN的单泛素化，因此诱导PTEN的核定位，结果与抑制肿瘤的存活，增殖，侵袭性质和转移性质有关的Akt途径， 因此具有显着降低同时表达PTEN和NEDD4-1的各种癌细胞的克隆潜能和肿瘤形成潜力的作用。 因此，本发明的p34基因表达抑制剂或p34蛋白活性抑制剂可以有效地用作癌症的治疗剂或转移抑制剂。

公开(公告)号：US09752151B2

公开(公告)日：2017-09-05

申请号：US14779874

申请日：2014-03-27

申请人： THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

发明人： Tae Won Kim ,  Dong Hoon Jin ,  Seung Woo Hong ,  Jai Hee Moon ,  Jae Sik Shin ,  Jin Sun Kim ,  Kyung Ah Jung ,  Jung Shin Lee ,  Eun Kyung Choi ,  Jae Lyun Lee ,  Yong Sang Hong ,  Kyu Pyo Kim ,  Ky Youb Nam ,  Bong Cheol Kim

IPC分类号： A01N43/52 ,  A61K31/415 ,  C12N15/113 ,  A61K31/4245 ,  C12Q1/68 ,  G01N33/50 ,  A23L33/13

CPC分类号： C12N15/1137 ,  A23L33/13 ,  A23V2002/00 ,  A61K31/4245 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/122 ,  C12N2310/14 ,  C12N2310/531 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011

摘要： The present invention relates to a composition for treatment or metastasis suppression of cancers which includes a p34 expression inhibitor or activity inhibitor as an active ingredient. According to the present invention, the p34 protein knock-down causes monoubiquitination of PTEN and accordingly nuclear localization of PTEN is induced, as a result, an Akt pathway which is related to survival, proliferation, invasive properties and metastatic properties of tumors is inhibited, and thus there is an effect of significantly reducing clonogenic potential and tumor forming potential of various cancer cells which simultaneously express PTEN and NEDD4-1. Consequently, the p34 gene expression inhibitor or p34 protein activity inhibitor according to the present invention can be effectively used as a treatment agent or a metastasis suppression agent for cancers.