公开(公告)号：US20220056124A1

公开(公告)日：2022-02-24

申请号：US17273538

申请日：2019-09-05

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Ningyan ZHANG ,  Dawei BU ,  Zhiqiang AN ,  Hui DENG ,  Philipp E. SCHERER

IPC: C07K16/26 ,  A61P35/00

Abstract: Aspects of the present invention relate to methods and reagents for increasing chemosensitivity to platinum-based chemotherapy. In one aspect, a method of increasing chemosensitivity to platinum-based chemotherapy is provided, comprising administering to a patient in need thereof an effective amount of an endotrophin-neutralizing agent. The agent can be a monoclonal antibody, or fragment thereof, capable of binding to the C5 domain of the alphas chain of collagen VI. In some embodiments, the method can further include administering an effective amount of thiazolidinedione to said patient.