公开(公告)号：US20230416721A1

公开(公告)日：2023-12-28

申请号：US18220864

申请日：2023-07-12

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Michael D. STORY ,  Narasimha Kumar KARANAM

IPC: C12N13/00 ,  A61P35/00 ,  A61K45/06

CPC classification number: C12N13/00 ,  A61P35/00 ,  A61K45/06

Abstract: Methods of reducing survival of cancer cells in a subject by applying alternating electric fields to the cancer cells and delivering at least one of an E2F inhibitor and a CDK4/6 inhibitor to the cancer cells are provided. In some instances, alternating electric fields are applied to the cancer cells at a frequency between 80 and 300 kHz. In some instances, at least a portion of the applying step is performed simultaneously with at least a portion of the delivering step. In some aspects, the alternating electric fields are applied to the cancer cells for at least 72 hours.

公开(公告)号：US20210292741A1

公开(公告)日：2021-09-23

申请号：US17208107

申请日：2021-03-22

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Michael D. STORY ,  Narasimha Kumar KARANAM

IPC: C12N13/00 ,  A61K45/06 ,  A61P35/00

Abstract: Methods of reducing survival of cancer cells in a subject by applying alternating electric fields to the cancer cells and delivering at least one of an E2F inhibitor and a CDK4/6 inhibitor to the cancer cells are provided. In some instances, alternating electric fields are applied to the cancer cells at a frequency between 80 and 300 kHz. In some instances, at least a portion of the applying step is performed simultaneously with at least a portion of the delivering step. In some aspects, the alternating electric fields are applied to the cancer cells for at least 72 hours.

公开(公告)号：US20230347173A1

公开(公告)日：2023-11-02

申请号：US18194513

申请日：2023-03-31

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Michael D. STORY ,  Debabrata SAHA ,  Narasimha Kumar KARANAM

IPC: A61N5/10 ,  A61P35/00 ,  A61K31/4725

CPC classification number: A61N5/1031 ,  A61K31/4725 ,  A61N5/1039 ,  A61P35/00

Abstract: A method of treating a tumor in a subject, the method comprises applying a tumor treating field to the tumor at a frequency between approximately 50 kHz and approximately 1,000 kHz; and delivering personalized ultra-fractionated adaptive radiotherapy (PULSAR) regimen.

公开(公告)号：US20220288404A1

公开(公告)日：2022-09-15

申请号：US17693108

申请日：2022-03-11

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Michael D. STORY ,  Narasimha Kumar KARANAM

IPC: A61N1/40 ,  A61K45/06 ,  A61P35/00

Abstract: A method of treating a tumor in a subject, the method comprises delivering an ATR inhibitor to the tumor, and applying a tumor treating field to the tumor at a frequency between approximately 50 kHz and approximately 1,000 kHz.