公开(公告)号：US20250115546A1

公开(公告)日：2025-04-10

申请号：US18809438

申请日：2024-08-20

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Kyoji TSUCHIKAMA ,  Yasuaki ANAMI ,  Chisato TSUCHIKAMA ,  Ningyang ZHANG ,  Zhiqiang AN

IPC: C07C247/04 ,  A61K31/40 ,  A61K45/06 ,  A61K47/68 ,  A61P35/00 ,  C07D209/20 ,  C07D403/12

Abstract: In one aspect, the present disclosure provides compounds of the formula: wherein the variables are as defined herein.
In another aspect, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure provides antibody drug conjugates comprising compounds of the present disclosure. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds and anti-body drug conjugates disclosed herein.

公开(公告)号：US20240059647A1

公开(公告)日：2024-02-22

申请号：US18173413

申请日：2023-02-23

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Kyoji TSUCHIKAMA ,  Yasuaki ANAMI ,  Chisato TSUCHIKAMA ,  Ningyang ZHANG ,  Zhiqiang AN

IPC: C07C247/04 ,  A61K47/68 ,  A61P35/00 ,  A61K31/40 ,  C07D209/20 ,  C07D403/12

CPC classification number: C07C247/04 ,  A61K47/6889 ,  A61P35/00 ,  A61K31/40 ,  C07D209/20 ,  C07D403/12 ,  A61K45/06

Abstract: In one aspect, the present disclosure provides compounds of the formula:




wherein the variables are as defined herein.
In another aspect, the present disclosure provides compounds of the formula:




wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure provides antibody drug conjugates comprising compounds of the present disclosure. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds and anti-body drug conjugates disclosed herein.