公开(公告)号：US12091441B2

公开(公告)日：2024-09-17

申请号：US17320174

申请日：2021-05-13

Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Kenan Christopher Garcia ,  Sonia S. Majri ,  Caleb R. Glassman ,  Leon Lih-Ren Su

IPC: A61K38/20 ,  A61P37/00 ,  C07K14/55 ,  C07K16/24 ,  C12N15/63 ,  A61K9/00 ,  A61K38/00

CPC classification number: C07K14/55 ,  A61P37/00 ,  C07K16/244 ,  C12N15/63 ,  A61K9/0024 ,  A61K38/00 ,  C07K2317/74 ,  C07K2317/92 ,  C07K2319/30 ,  C07K2319/31

Abstract: Provided herein, inter alia, are human interleukin-2 (IL-2) muteins or variants thereof. In particular, provided herein are IL-2 muteins that have a decreased binding capacity for IL-2Rγ. Such IL-2 muteins are useful, for example, as IL-2 partial agonist in applications where reduction or inhibition of one or more IL-2 and/or IL-15 functions is useful (e.g., in the treatment of autoimmune diseases or conditions). Also provided are nucleic acids encoding such IL-2 muteins, methods of making such IL-2 muteins, pharmaceutical compositions that include such IL-2 muteins and methods of treatment using such pharmaceutical compositions.