公开(公告)号：US20230365986A1

公开(公告)日：2023-11-16

申请号：US18117995

申请日：2023-03-06

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

发明人： Ioannis Tzanetakis ,  Jing Zhou

IPC分类号： C12N15/82 ,  C07K7/08

CPC分类号： C12N15/8283 ,  C07K7/08

摘要： Orthotospovirus virions travel through the thrips foregut and enter midgut epithelial cells through the interaction between virus glycoproteins and cellular receptors with several protein motifs thought to be involved in the interaction. Single, double and triple mutant polypeptides in the soybean vein necrosis virus (SVNV)/Neohydatothrips variabilis system are provided herein and several are shown to block viral transmission from the thrips to the soybean plants. Methods for inhibiting viral transmission using these polypeptides or constructs comprising polynucleotides encoding peptides are also provided herein.

公开(公告)号：US11597945B2

公开(公告)日：2023-03-07

申请号：US16913721

申请日：2020-06-26

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

发明人： Ioannis Tzanetakis ,  Jing Zhou

IPC分类号： C12N15/82 ,  C07K7/08

摘要： Orthotospovirus virions travel through the thrips foregut and enter midgut epithelial cells through the interaction between virus glycoproteins and cellular receptors with several protein motifs thought to be involved in the interaction. Single, double and triple mutant polypeptides in the soybean vein necrosis virus (SVNV)/Neohydatothrips variabilis system are provided herein and several are shown to block viral transmission from the thrips to the soybean plants. Methods for inhibiting viral transmission using these polypeptides or constructs comprising polynucleotides encoding peptides are also provided herein.

公开(公告)号：US20210071196A1

公开(公告)日：2021-03-11

申请号：US16913721

申请日：2020-06-26

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

发明人： Ioannis Tzanetakis ,  Jing Zhou

IPC分类号： C12N15/82 ,  C07K7/08

摘要： Orthotospovirus virions travel through the thrips foregut and enter midgut epithelial cells through the interaction between virus glycoproteins and cellular receptors with several protein motifs thought to be involved in the interaction. Single, double and triple mutant polypeptides in the soybean vein necrosis virus (SVNV)/Neohydatothrips variabilis system are provided herein and several are shown to block viral transmission from the thrips to the soybean plants. Methods for inhibiting viral transmission using these polypeptides or constructs comprising polynucleotides encoding peptides are also provided herein.