公开(公告)号：US20210322548A1

公开(公告)日：2021-10-21

申请号：US17239983

申请日：2021-04-26

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

发明人： Lai-Ming YUNG ,  Paul B. YU

IPC分类号： A61K39/395 ,  A61P11/00

摘要： The technology described herein is directed to methods and compositions for the treatment of hypertension, e.g. pulmonary arterial hypertension, relating to inhibition of TGFβ1, TGFβ3, and/or GDF-15.

公开(公告)号：US20200323955A1

公开(公告)日：2020-10-15

申请号：US16851287

申请日：2020-04-17

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  ACCELERON PHARMA, INC.

发明人： Paul B. YU ,  Asya GRINBERG ,  Dianne S. SAKO ,  Roselyne CASTONGUAY ,  Rita STEEVES ,  Ravindra KUMAR

IPC分类号： A61K38/17 ,  C07K14/71 ,  A61P9/12

摘要： In some aspects, the invention teaches pharmaceutical compositions that include a TGF-β ligand trap, and methods of using a TGF-β ligand trap to treat, prevent, or reduce the progression rate of pulmonary hypertension (PH). The invention also provides methods of using a TGF-β ligand trap to treat, prevent, or reduce the progression rate of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, right ventricular hypertrophy, diseases associated with excessive TGF-β signaling, diseases associated with excessive GDF15 signaling, and diseases associated with excessive PAI-1 signaling. The invention further provides methods of using a TGF-β ligand trap to reduce right ventricular systolic pressure in a subject.

公开(公告)号：US20170202918A1

公开(公告)日：2017-07-20

申请号：US15327741

申请日：2015-08-03

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

发明人： Lai-Ming YUNG ,  Paul B. YU

IPC分类号： A61K38/18 ,  C07K14/495

CPC分类号： A61K38/1841 ,  A61K45/06 ,  C07K14/495 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/74

摘要： The technology described herein is directed to methods and compositions for the treatment of hypertension, e.g. pulmonary arterial hypertension, relating to inhibition of TGFβ1, TGFβ3, and/or GDF-15.