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公开(公告)号：US20220251651A1
公开(公告)日：2022-08-11
申请号：US15759159
申请日：2016-09-09
IPC分类号： C12Q1/6881 , A61K31/45
摘要： In one aspect, the present invention features method of identifying a cell resistant to a modulator of Cereblon (CRBN). In another aspect, the present invention features a method of characterizing sensitivity of a subject to a modulator of CRBN. In yet another aspect, the present invention features a method of monitoring sensitivity of a subject to a modulator of CRBN.
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公开(公告)号：US20220017938A1
公开(公告)日：2022-01-20
申请号：US17496578
申请日：2021-10-07
申请人： THE BROAD INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
摘要： In one aspect, the invention features a method for identifying a drug-modulated polypeptide substrate of cereblon (CRBN). In another aspect, the invention features a method of identifying a polypeptide target of a modulator of CRBN. In yet another aspect, the invention provides methods of monitoring or characterizing the sensitivity of a subject to a modulator of CRBN.
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公开(公告)号：US20190071731A1
公开(公告)日：2019-03-07
申请号：US15759168
申请日：2016-09-09
申请人： TARJEI MIKKELSEN , BENJAMIN LEVINE EBERT , QUINLAN SIEVERS , THE BROAD INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
IPC分类号： C12Q1/6886 , C12Q1/02 , A61K31/454 , A61K31/4035 , A61P35/00
摘要： In one aspect, the invention features a method for identifying a drug-modulated polypeptide substrate of cereblon (CRBN). In another aspect, the invention features a method of identifying a polypeptide target of a modulator of CRBN. In yet another aspect, the invention provides methods of monitoring or characterizing the sensitivity of a subject to a modulator of CRBN.
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