专利检索 ap:("THE BROAD INSTITUTE INC." OR "DANA-FARBER CANCER INSTITUTE, INC") AND inv:"David K. THOMAS" 第 1 页

1.

发明申请
COMPOSITIONS AND METHODS FOR IDENTIFYING AND TREATING CACHEXIA OR PRE-CACHEXIA 审中-公开

公开(公告)号：US20170240632A1

公开(公告)日：2017-08-24

申请号：US15519212

申请日：2015-10-16

申请人： THE BROAD INSTITUTE INC. , DANA-FARBER CANCER INSTITUTE, INC

发明人： David K. THOMAS , Todd GOLUB

IPC分类号： C07K16/28 , G01N33/68

CPC分类号： C07K16/2803 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/6893 , G01N2800/10

摘要： The invention provides therapeutic, engineered protein/peptide compositions comprising e.g., RAGE antibodies, T-cell receptors to target a RAGE receptor (including soluble forms thereof) directly and/or via differential competition with one or more pre-cachexia and/or cachexia-associated RAGE ligands or markers.