公开(公告)号：US09879027B2

公开(公告)日：2018-01-30

申请号：US15494538

申请日：2017-04-23

申请人： THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY ,  GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE

发明人： Kefang Lai ,  Xiaodong Liu ,  Bonian Zhong ,  Shan Zhong ,  Chuqin Huang

IPC分类号： A61K36/00 ,  C07D493/04 ,  A61K36/264 ,  A61K31/36

CPC分类号： C07D493/04 ,  A61K31/36 ,  A61K36/264 ,  A61K2236/13 ,  A61K2236/33 ,  A61K2236/37 ,  A61K2236/39 ,  Y02P20/544

摘要： The invention discloses a method for extracting high-purity asarinin and use thereof. The method comprises: putting crude asarum powder in an SFE-CO2 device; under the conditions that an extraction kettle has a pressure of 30-40 Mpa and a temperature of 45-70° C., separating kettles I and II have a pressure of 5-10 Mpa, a temperature of 30-50° C. and the flow rate of CO2 is 35-60 L/h, extracting for 60-240 min to obtain total volatile oil of asarum; standing the total volatile oil of asarum for 24-72 h at a low temperature, and carrying out suction filtration under reduced pressure to obtain crude asarinin; and re-crystallizing the crude asarinin in absolute ethanol twice to obtain pure asarinin. It is found for the first time that asarinin has a good cough-relieving activity and thus can be used in preparing medicines for treating various types of coughs.