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公开(公告)号：US20180018816A1
公开(公告)日：2018-01-18
申请号：US15623363
申请日：2017-06-14
申请人： THE FIRST AFFILIATED HOSPITAL OF SUN YAT-SEN UNIVERSITY , SCHOOL OF DATA AND COMPUTER SCIENCE OF SUN YAT-SEN UNIVERSITY , NATIONAL SUPERCOMPUTER CENTRE IN GUANGZHOU OF SUN YAT-SEN UNIVERSITY
发明人： Liwei Yan , Shuang Zhu , Xiaolin Liu , Jian Qi , Qingtang Zhu , Yao Lu , Yongze Guo , Sha Yu , Yutong Lu , Xi Zhang , Yunfei Du , Tao Lin
CPC分类号： G06T17/00 , G01N1/30 , G01N2001/302 , G01N2001/305 , G06T7/10 , G06T15/04 , G06T2207/10081 , G06T2207/30004 , G06T2210/41 , G06T2211/40 , G06T2215/16
摘要： The present invention relates to fields of clinical application of nerve defect repair and the medical three-dimensional (3D) printing technology, and provides an integrated visualization method for three-dimensional (3D) reconstruction of internal structure of human peripheral nerves. The method comprises the following steps: obtaining human peripheral nerves, preparing nerve specimens ex vivo by staining with an iodine preparation in combination with a freeze-drying method; scanning the pretreated peripheral nerves using Micro CT to acquire lossless two-dimensional images, and performing binarization processing to the two-dimensional images, then conducting image segmentation based on textural features to acquire images of nerve fascicles; finally, reconstructing the segmented images into a visualization model by using a supercomputer.
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公开(公告)号：US10147228B2
公开(公告)日：2018-12-04
申请号：US15623363
申请日：2017-06-14
申请人： THE FIRST AFFILIATED HOSPITAL OF SUN YAT-SEN UNIVERSITY , SCHOOL OF DATA AND COMPUTER SCIENCE OF SUN YAT-SEN UNIVERSITY , NATIONAL SUPERCOMPUTER CENTRE IN GUANGZHOU OF SUN YAT-SEN UNIVERSITY
发明人： Liwei Yan , Shuang Zhu , Xiaolin Liu , Jian Qi , Qingtang Zhu , Yao Lu , Yongze Guo , Sha Yu , Yutong Lu , Xi Zhang , Yunfei Du , Tao Lin
摘要： The present invention relates to fields of clinical application of nerve defect repair and the medical three-dimensional (3D) printing technology, and provides an integrated visualization method for three-dimensional (3D) reconstruction of internal structure of human peripheral nerves. The method comprises the following steps: obtaining human peripheral nerves, preparing nerve specimens ex vivo by staining with an iodine preparation in combination with a freeze-drying method; scanning the pretreated peripheral nerves using Micro CT to acquire lossless two-dimensional images, and performing binarization processing to the two-dimensional images, then conducting image segmentation based on textural features to acquire images of nerve fascicles; finally, reconstructing the segmented images into a visualization model by using a supercomputer.
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公开(公告)号：US10825179B2
公开(公告)日：2020-11-03
申请号：US16246544
申请日：2019-01-13
申请人： THE FIRST AFFILIATED HOSPITAL OF SUN YAT-SEN UNIVERSITY , SCHOOL OF DATA AND COMPUTER SCIENCE OF SUN YAT-SEN UNIVERSITY
发明人： Jian Qi , Qingtang Zhu , Liwei Yan , Zhi Yao , Xiaolin Liu , Yao Lu , Shouliang Liu , Tao Wang , Tao Lin
摘要： The present invention provides a method for establishing a biomimetic nerve graft model for nerve fascicles of the extremities, which comprises the steps of: establishing a database of fascicles structures from nerve fascicles of the extremities with an imaging technique; obtaining information of a defective nerve trunk to be repaired of the extremities; and matching and fitting the information of the defective nerve trunk to be repaired of the extremities with/to the data in the database of fascicles structures, to establish a biomimetic nerve graft model that conforms to the characteristics of fascicles microstructure for nerve fascicles of the defective nerve trunk. In the present invention, the imaging technique and clinical data are fully utilized, to establish a biomimetic nerve graft model conforming to the characteristics of fascicles microstructure for varying types of detects, thus providing more accurate model information for repair of nerve trunk defects in the extremities.
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4.发明申请公开(公告)号：US20200027213A1
公开(公告)日：2020-01-23
申请号：US16246544
申请日：2019-01-13
申请人： THE FIRST AFFILIATED HOSPITAL OF SUN YAT-SEN UNIVERSITY , SCHOOL OF DATA AND COMPUTER SCIENCE OF SUN YAT-SEN UNIVERSITY
发明人： Jian Qi , Qingtang Zhu , Liwei Yan , Zhi Yao , Xiaolin Liu , Yao Lu , Shouliang Liu , Tao Wang , Tao Lin
摘要： The present invention provides a method for establishing a biomimetic nerve graft model for nerve fascicles of the extremities, which comprises the steps of: establishing a database of fascicles structures from nerve fascicles of the extremities with an imaging technique; obtaining information of a defective nerve trunk to be repaired of the extremities; and matching and fitting the information of the defective nerve trunk to be repaired of the extremities with/to the data in the database of fascicles structures, to establish a biomimetic nerve graft model that conforms to the characteristics of fascicles microstructure for nerve fascicles of the defective nerve trunk. In the present invention, the imaging technique and clinical data are fully utilized, to establish a biomimetic nerve graft model conforming to the characteristics of fascicles microstructure for varying types of detects, thus providing more accurate model information for repair of nerve trunk defects in the extremities.
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5.发明授权公开(公告)号：US10908246B2
公开(公告)日：2021-02-02
申请号：US16379787
申请日：2019-04-09
发明人： Qingtang Zhu , Jian Qi , Liwei Yan , Zhi Yao , Xiaolin Liu
摘要： The present invention provides a method for three-dimensional reconstruction of fascicular structure of human peripheral nerve, which comprises the steps of: obtaining human peripheral nerve and preparing a peripheral nerve sample; immersing the peripheral nerve sample into a liquid; setting scan parameters of Micro-MRI, scanning the peripheral nerve sample by Micro-MRI, to acquire image data of the peripheral nerve sample in the liquid environment; and three-dimensional reconstructing a structural model of the peripheral nerve sample based on the image data. By means of the method according to the present invention, high-quality scanned images are obtained without destroying the morphology and physical and chemical properties of peripheral nerve, so as to obtain a precise three-dimensional visualization model of peripheral nerve fascicle.
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6.发明申请公开(公告)号：US20190235039A1
公开(公告)日：2019-08-01
申请号：US16379787
申请日：2019-04-09
发明人： Qingtang Zhu , Jian Qi , Liwei Yan , Zhi Yao , Xiaolin Liu
CPC分类号： G01R33/543 , G01R33/30 , G06T11/003 , G06T17/00 , G06T17/10 , G06T2207/10088 , G06T2207/30004 , G06T2210/41
摘要： The present invention provides a method for three-dimensional reconstruction of fascicular structure of human peripheral nerve, which comprises the steps of: obtaining human peripheral nerve and preparing a peripheral nerve sample; immersing the peripheral nerve sample into a liquid; setting scan parameters of Micro-MRI, scanning the peripheral nerve sample by Micro-MRI, to acquire image data of the peripheral nerve sample in the liquid environment; and three-dimensional reconstructing a structural model of the peripheral nerve sample based on the image data. By means of the method according to the present invention, high-quality scanned images are obtained without destroying the morphology and physical and chemical properties of peripheral nerve, so as to obtain a precise three-dimensional visualization model of peripheral nerve fascicle.
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