公开(公告)号：US20220404639A1

公开(公告)日：2022-12-22

申请号：US17753253

申请日：2020-09-08

Applicant: THE HONG KONG POLYTECHNIC UNIVERSITY

Inventor： Siu Yin LAM ,  Yan Yin TSE ,  Chi Ho TO

IPC: G02C7/04

Abstract: Provided herein is concentric annular multi-zone lens for retarding myopia progression in a human eye. The lens comprises: a plurality of correcting zones for forming a focused image on a retina of the human eye so as to correct refractive error of the human eye, wherein the correcting zone having a similar refractive power; a plurality of defocusing zones for forming images anterior to the retina so as to generate myopic defocus; and a defocusing power increasing region, in which refractive powers of defocusing zones being increasingly relatively positive towards the periphery of the lens so as to generate larger amplitude of the myopic defocus at the periphery of the retina; wherein the plurality of correcting zones and the plurality of defocusing zones are alternated in the concentric annular multi-zone lens.

公开(公告)号：US20240342149A1

公开(公告)日：2024-10-17

申请号：US18332751

申请日：2023-06-12

Applicant: Centre for Eye and Vision Research Limited ,  The Hong Kong Polytechnic University

Inventor： Chuen LAM ,  Ying Hon SZE ,  Yan Yin TSE

IPC: A61K31/4439 ,  A61P27/10

CPC classification number: A61K31/4439 ,  A61P27/10

Abstract: A pharmacologic treatment of refractive disorders, specifically myopia or hyperopia, by targeting the PPAR signaling pathway using a PPARγ agonist without any binding to PPARα. It is demonstrated that the PPARγ agonist modulates ocular growth through therapeutic intervention at the protein level of the PPAR signaling pathway. The effectiveness of the PPARγ agonist in regulating the PPAR signaling pathway and its associated proteins, as evidenced by experiments using a lens-induced myopia (LIM) animal model. More particularly, it is also demonstrated that the pharmacological reduction of myopic eye growth in terms of biometrics with dosage effect through the administration of the PPARγ agonist.

公开(公告)号：US20240037715A1

公开(公告)日：2024-02-01

申请号：US18360850

申请日：2023-07-28

Applicant: Benjamin Simon THOMPSON ,  Centre for Eye and Vision Research Limited ,  The Hong Kong Polytechnic University

Inventor： Benjamin Simon THOMPSON ,  Chi Ho TO ,  Yan Yin TSE ,  Ka Man CHUN ,  Elie Aymard Jonathan DE LESTRANGE-ANGINIEUR

IPC: G06T5/00 ,  G02B27/00

CPC classification number: G06T5/002 ,  G02B27/0093 ,  G06T2207/30041

Abstract: Methods, systems and devices for preventing and/or retarding myopia onset and/or progression are provided. Particularly, the system for preventing and/or retarding myopia onset and/or progression including an eye tracker, a display, a controller, and a dynamic blurring filter for the visual content on the display. The display is first presented to a subject, then the eye tracker is employed to detect the movement and the location of the subject's eyes and generate a tracking signal. The tracking signal is further processed by the controller to determine a gaze point of the subject's eye on the display. Based on the gaze point, a dynamic blurring filter is created and applied onto the display.

公开(公告)号：US20250144055A1

公开(公告)日：2025-05-08

申请号：US18501136

申请日：2023-11-03

Applicant: THE HONG KONG POLYTECHNIC UNIVERSITY

Inventor： Chuen LAM ,  Jing Fang BIAN ,  Yan Yin TSE ,  Chi ho TO

IPC: A61K31/19 ,  A61P27/10

Abstract: A method for reducing myopia progression. In particular, the method includes administering to a subject a compound represented by the following formula or a composition comprising an effective amount of the same: or a pharmaceutically accept salt thereof, in which the compound can target and inhibit catechol-O-methyltransferase, up-regulate retinal dopamine expression and change the choroidal thickness of a uvea of the subject, where an increase in choroidal thickness indicates a reduction in myopia progression.

公开(公告)号：US20150109574A1

公开(公告)日：2015-04-23

申请号：US14581003

申请日：2014-12-23

Applicant: The Hong Kong Polytechnic University

Inventor： Yan Yin TSE ,  Chi Ho TO ,  Siu Yin LAM

IPC: G02C7/04 ,  G02C7/06

CPC classification number: G02C7/044 ,  G02C7/042 ,  G02C7/066 ,  G02C2202/24

Abstract: A method for retarding the progression of myopia in a human eye, the method comprising: providing (41) a concentric annular multi-zone refractive lens including: at least one correcting zone of optical power for correcting (42) refractive error, and at least one defocusing zone for projecting (43) at least one non-homogenous defocused image in front of at least a part of retina to inhibit myopic eye growth, the at least one defocusing zone having at least one less negative power; wherein the correcting and defocusing zones are alternated (45) in the lens and the zones are connected (46) to each other through integrated progressive transition curves.

Abstract translation: 一种用于延缓人眼近视进展的方法，所述方法包括：提供（41）同心环形多区域折射透镜，其包括：用于校正（42）屈光不正的至少一个光学矫正区域，至少 一个散焦区域，用于在视网膜的至少一部分前方突出（43）至少一个不均匀的散焦图像以抑制近视眼生长，所述至少一个散焦区域具有至少一个较小的负功率; 其中所述校正和散焦区域在所述透镜中交替（45），并且所述区域通过集成渐进转换曲线彼此连接（46）。