专利检索 ap:("THE MEDICAL COLLEGE OF WISCONSIN, INC." OR "AIX-MARSEILLE UNIVERSITE") AND inv:"Micael Joël Hardy" 第 1 页

1.

发明授权
Mito-magnolol compounds and methods of synthesis and use thereof 有权

公开(公告)号：US11612610B2

公开(公告)日：2023-03-28

申请号：US17397672

申请日：2021-08-09

申请人： The Medical College of Wisconsin, Inc. , AIX-MARSEILLE UNIVERSITE

发明人： Balaraman Kalyanaraman , Jacek Michal Zielonka , Gang Cheng , Micael Joël Hardy , Olivier Ouari

IPC分类号： C07F9/54 , A61K31/66 , A61P35/00 , A61K45/06

摘要： The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.

2.

发明授权
Mito-magnolol compounds and methods of synthesis and use thereof 有权

公开(公告)号：US11083739B2

公开(公告)日：2021-08-10

申请号：US16714461

申请日：2019-12-13

申请人： THE MEDICAL COLLEGE OF WISCONSIN, INC. , AIX-MARSEILLE UNIVERSITE

发明人： Balaraman Kalyanaraman , Jacek Michal Zielonka , Gang Cheng , Micael Joël Hardy , Olivier Ouari

IPC分类号： C07F9/54 , A61K31/66 , A61P35/00 , A61K45/06

摘要： The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.

3.

发明申请
Mito-Magnolol Compounds and Methods of Synthesis and Use Thereof 有权

公开(公告)号：US20220211727A1

公开(公告)日：2022-07-07

申请号：US17397672

申请日：2021-08-09

申请人： The Medical College of Wisconsin, Inc. , AIX-MARSEILLE UNIVERSITE

发明人： Balaraman Kalyanaraman , Jacek Michal Zielonka , Gang Cheng , Micael Joël Hardy , Olivier Ouari

IPC分类号： A61K31/66 , A61P35/00 , A61K45/06 , C07F9/54

摘要： The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.

4.

发明申请
MITO-MAGNOLOL COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF 审中-公开

公开(公告)号：US20200222433A1

公开(公告)日：2020-07-16

申请号：US16714461

申请日：2019-12-13

申请人： THE MEDICAL COLLEGE OF WISCONSIN, INC. , AIX-MARSEILLE UNIVERSITE

发明人： Balaraman Kalyanaraman , Jacek Michal Zielonka , Gang Cheng , Micael Joël Hardy , Olivier Ouari

IPC分类号： A61K31/66 , A61K45/06 , A61P35/00 , C07F9/54

摘要： The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.

5.

发明申请
Mitochondria-Targeted Atovaqone: A More Potent and More Effective Antitumor, Antimicrobial, and Antimalarial Drug 有权

公开(公告)号：US20230017373A1

公开(公告)日：2023-01-19

申请号：US17770924

申请日：2020-10-26

申请人： The Medical College of Wisconsin, Inc. , Aix-Marseille Université

发明人： Balaraman Kalyanaraman , Gang Cheng , Micael Joël Hardy

IPC分类号： A61K31/66 , C07F9/535 , C07F9/54 , C07C49/84 , A61P35/00 , A61K31/122 , A61K45/06

摘要： The present invention provides novel mitochondria-targeted Atovaquone compounds (Mito-ATO), a mitochondria-targeted derivative of Atovaquone, and methods of using such compounds. Methods of treating cancer using mito-ATO are also provided. Methods of enhancing an anti-tumor immune response by administering mito-ATO are further provided.