公开(公告)号：US20210187260A1

公开(公告)日：2021-06-24

申请号：US16756938

申请日：2018-10-17

申请人： THE METHODIST HOSPITAL SYSTEM

发明人： Marco FARINA ,  Andrea BALLERINI ,  Daniel W. FRAGA ,  Usha Ramachandran THEKKEDATH ,  Omaima M. SABEK ,  Ahmed Osama GABER ,  Alessandro GRATTONI

IPC分类号： A61M31/00 ,  A61K9/00 ,  A61K45/06 ,  C08L67/04

摘要： Disclosed herein are devices for use in transplanting cells. The devices can include a housing defining a cavity; and a support structure separating the cavity into a cell chamber and a reservoir chamber, wherein the support structure comprises a membrane for fluid communication between the cell chamber and reservoir chamber. The cell chamber can define a first opening comprising a microstructure containing an array of micro-channels, each having a diameter to facilitate growth of vascular tissues; and an array of micro-reservoirs, each having a diameter to facilitate housing of cell aggregates individually. The membrane can define a surface area that is at least 50% of a total surface area of the support structure. Methods of treating a subject for a disease condition, such as diabetes, are also disclosed.