公开(公告)号：US11971535B2

公开(公告)日：2024-04-30

申请号：US16853512

申请日：2020-04-20

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Juliet T. Gopinath ,  Emily A. Gibson ,  Victor M. Bright ,  Richard Weir ,  Diego Restrepo ,  Baris Ozbay

IPC: G02B3/14 ,  G02B6/06 ,  G02B21/00 ,  G02B23/24 ,  G02B23/26 ,  G02B26/00 ,  H04N23/56 ,  H04N23/50

CPC classification number: G02B23/243 ,  G02B3/14 ,  G02B6/06 ,  G02B21/0032 ,  G02B21/006 ,  G02B21/0076 ,  G02B23/2446 ,  G02B23/2469 ,  G02B23/26 ,  G02B26/005 ,  H04N23/56 ,  H04N23/555

Abstract: The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.

公开(公告)号：US11835706B2

公开(公告)日：2023-12-05

申请号：US16853512

申请日：2020-04-20

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Juliet T. Gopinath ,  Emily A. Gibson ,  Victor M. Bright ,  Richard Weir ,  Diego Restrepo ,  Baris Ozbay

IPC: G02B3/14 ,  G02B23/24 ,  G02B26/00 ,  H04N23/56 ,  G02B6/06 ,  G02B21/00 ,  G02B23/26 ,  H04N23/50

CPC classification number: G02B23/243 ,  G02B3/14 ,  G02B6/06 ,  G02B21/006 ,  G02B21/0032 ,  G02B21/0076 ,  G02B23/2446 ,  G02B23/2469 ,  G02B23/26 ,  G02B26/005 ,  H04N23/56 ,  H04N23/555

Abstract: The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.

公开(公告)号：US20200348505A1

公开(公告)日：2020-11-05

申请号：US16853512

申请日：2020-04-20

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Juliet T. Gopinath ,  Emily A. Gibson ,  Victor M. Bright ,  Richard Weir ,  Diego Restrepo ,  Baris Ozbay

IPC: G02B23/24 ,  G02B3/14 ,  G02B26/00 ,  G02B6/06 ,  G02B21/00 ,  G02B23/26 ,  H04N5/225

Abstract: The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.

公开(公告)号：US20200292810A1

公开(公告)日：2020-09-17

申请号：US16753615

申请日：2018-10-03

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Juliet Gopinath ,  Mo Zohrabi ,  Victor M. Bright ,  Omkar Supekar ,  Robert H. Cormack ,  Emily Gibson ,  Connor McCullough

IPC: G02B27/00 ,  G02B21/06

Abstract: The present disclosure relates generally to methods and systems useful in imaging applications, especially biological imaging applications, and applications in the metrology, atmospheric, scientific and medical fields. In one aspect, the disclosure provides a method of imaging an object, including illuminating the object with incident radiation through one or more adaptive optical elements; receiving transmitted radiation from the object at a photodetector to provide a base image; and performing the following steps one or more times: adjusting the one or more adaptive optical elements, the adjustment including modifying an optical transfer function of the one or more adaptive optical elements, and receiving transmitted radiation from the object at the photodetector to provide an adjusted image; wherein the adjustment and receiving steps are performed until the adjusted image has substantially reduced aberrations compared to the base image.

公开(公告)号：US10171919B2

公开(公告)日：2019-01-01

申请号：US15596458

申请日：2017-05-16

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Victor M. Bright ,  Joseph J. Brown

IPC: H04R23/00 ,  B82B3/00 ,  B82Y40/00 ,  B81C1/00 ,  H01L51/00 ,  H04R31/00

Abstract: In one aspect, the present invention provides nano-scale heaters, such as nano-scale thermoacoustic loudspeakers comprising suspended metal nanobridges prepared using atomic layer deposition (ALD). The loudspeakers of the invention are capable of producing audible sound when stimulated with an electrical current or other energetic stimulus. In another aspect, the present invention provides methods of preparing and using such nanodevices.

公开(公告)号：US10598919B2

公开(公告)日：2020-03-24

申请号：US15449975

申请日：2017-03-05

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Juliet T. Gopinath ,  Victor M. Bright ,  Andrew M. Jones

IPC: G02B26/00 ,  G02B3/12 ,  G02B26/02 ,  G02B26/08

Abstract: Electrowetting-actuated optical shutters based on total internal reflection or beam steering. An electrowetting cell contains a conducting liquid and a non-conducting liquid configured to form a liquid-liquid interface extending to the inner walls of the cell. A beam of light is directed to the liquid-liquid interface at an angle near the total internal reflection angle of the interface. Voltage changes the shape of the liquid-liquid interface, without separating it from the inner walls of the cell. Thus, when depending on the voltage applied, the beam is either transmitted in part or substantially totally internal reflected.

公开(公告)号：US20200073100A1

公开(公告)日：2020-03-05

申请号：US16557935

申请日：2019-08-30

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Emily A. Gibson ,  Cristin Welle ,  Diego Restrepo ,  Douglas Shepherd ,  Juliet T. Gopinath ,  Victor M. Bright ,  Robert H. Cormack ,  loannis Kymissis

IPC: G02B21/00 ,  G02B27/02

Abstract: The present disclosure provides methods and systems for modulation and imaging of tissue. Various embodiments relate to optical interfaces and methods for rapid volumetric neural sensing and modulation, using structured illumination and

公开(公告)号：US11675181B2

公开(公告)日：2023-06-13

申请号：US16853512

申请日：2020-04-20

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Juliet T. Gopinath ,  Emily A. Gibson ,  Victor M. Bright ,  Richard Weir ,  Diego Restrepo ,  Baris Ozbay

IPC: G02B3/14 ,  G02B23/24 ,  G02B26/00 ,  H04N23/56 ,  G02B6/06 ,  G02B21/00 ,  G02B23/26 ,  H04N23/50

CPC classification number: G02B23/243 ,  G02B3/14 ,  G02B6/06 ,  G02B21/006 ,  G02B21/0032 ,  G02B21/0076 ,  G02B23/2446 ,  G02B23/2469 ,  G02B23/26 ,  G02B26/005 ,  H04N23/56 ,  H04N23/555

Abstract: The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.

公开(公告)号：US11067511B2

公开(公告)日：2021-07-20

申请号：US16576553

申请日：2019-09-19

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Joseph J. Brown ,  Omkar D. Supekar ,  Victor M. Bright ,  Juliet T. Gopinath ,  Alan R. Greenberg

IPC: G01J3/44 ,  G01N21/65 ,  B01D65/10 ,  G01N17/00

Abstract: Methods and devices for real-time detection of fouling chemistry are described herein. In one aspect, a method of detecting and characterizing fouling of a membrane used for separation in a fluid-based system can include illuminating the membrane with one or more light sources, collecting Raman spectroscopy data from the membrane, and based on the Raman data, determining at least one selected from the group consisting of: presence or absence of membrane fouling, severity of membrane fouling, and composition of the membrane fouling, where the Raman spectroscopy is selected from the group consisting of Coherent Anti-Stokes Raman Scattering (CARS), Stimulated Raman Scattering (SRS), and spontaneous Raman Scattering.

公开(公告)号：US20190265460A1

公开(公告)日：2019-08-29

申请号：US16288176

申请日：2019-02-28

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Juliet T. Gopinath ,  Victor M. Bright ,  Mo Zohrabi ,  Omkar D. Supekar ,  Robert H. Cormack ,  Wei Yang Lim

IPC: G02B26/00 ,  G02B3/12

Abstract: A tunable optical electrowetting element having a liquid-liquid interface shape controlled by an applied voltage. Circuitry for applying a voltage to the electrowetting element is configured to apply a shaped voltage signal comprising a first fast-rising signal combined with a second fast-rising signal. The second signal is selected to damp oscillations in the liquid-liquid interface caused by the first signal.