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公开(公告)号:US20220143170A1
公开(公告)日:2022-05-12
申请号:US17587953
申请日:2022-01-28
Inventor: Theodore Randolph , Robert Garcea , Kimberly J. Hassett
IPC: A61K39/12 , A61K39/295 , A61K45/06
Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes.