公开(公告)号：US20220143170A1

公开(公告)日：2022-05-12

申请号：US17587953

申请日：2022-01-28

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BOYD CORPORATE

Inventor： Theodore Randolph ,  Robert Garcea ,  Kimberly J. Hassett

IPC: A61K39/12 ,  A61K39/295 ,  A61K45/06

Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes.