公开(公告)号：US20210261925A1

公开(公告)日：2021-08-26

申请号：US17228211

申请日：2021-04-12

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： David H. Sherman ,  Amy E. Fraley ,  Ashootosh Tripathi

IPC: C12N9/02 ,  A61K31/4995 ,  C12P17/18

Abstract: The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of complex chemical compounds and methods of inhibiting the contraction of smooth muscle in mammals.

公开(公告)号：US11692176B2

公开(公告)日：2023-07-04

申请号：US17228211

申请日：2021-04-12

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： David H. Sherman ,  Amy E. Fraley ,  Ashootosh Tripathi

IPC: C12N15/52 ,  C12N9/02 ,  A61K31/4995 ,  C12P17/18

CPC classification number: C12N9/0071 ,  A61K31/4995 ,  C12P17/182

Abstract: The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of complex chemical compounds and methods of inhibiting the contraction of smooth muscle in mammals.

公开(公告)号：US11008553B2

公开(公告)日：2021-05-18

申请号：US16516102

申请日：2019-07-18

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： David H. Sherman ,  Amy E. Fraley ,  Ashootosh Tripathi

IPC: C12P5/00 ,  C12N9/02 ,  A61K31/4995 ,  C12P17/18

Abstract: The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of complex chemical compounds and methods of inhibiting the contraction of smooth muscle in mammals.