公开(公告)号：US20200247868A1

公开(公告)日：2020-08-06

申请号：US16782417

申请日：2020-02-05

Applicant: The Regents of The University Of Michigan

Inventor： Challice L. Bonifant ,  Alnawaz Rehemtulla ,  David M. Markovitz

IPC: C07K14/725 ,  C07K14/705 ,  C12N5/0783 ,  A61K35/17 ,  A61P35/00

Abstract: The disclosure provides a chimeric antigen receptor (CAR) polypeptide having an antigen binding domain comprising an extracellular lectin which specifically binds to glycoproteins expressed on the surface of target cells. Also provided herein are engineered lymphocytes expressing the CAR polypeptide, a nucleic acid molecule encoding the CAR polypeptide, and methods of treating cancer.

公开(公告)号：US11760786B2

公开(公告)日：2023-09-19

申请号：US16782417

申请日：2020-02-05

Applicant: The Regents of The University Of Michigan

Inventor： Challice L. Bonifant ,  Alnawaz Rehemtulla ,  David M. Markovitz

IPC: C07K14/725 ,  C07K14/705 ,  A61K35/17 ,  A61P35/00 ,  C12N5/0783

CPC classification number: C07K14/7051 ,  A61K35/17 ,  A61P35/00 ,  C07K14/70517 ,  C07K14/70575 ,  C12N5/0636 ,  C07K2319/02

Abstract: The disclosure provides a chimeric antigen receptor (CAR) polypeptide having an antigen binding domain comprising an extracellular lectin which specifically binds to glycoproteins expressed on the surface of target cells. Also provided herein are engineered lymphocytes expressing the CAR polypeptide, a nucleic acid molecule encoding the CAR polypeptide, and methods of treating cancer.

公开(公告)号：US20240124548A1

公开(公告)日：2024-04-18

申请号：US18363417

申请日：2023-08-01

Applicant: The Regents of The University of Michigan

Inventor： Challice L. Bonifant ,  Alnawaz Rehemtulla ,  David M. Markovitz

IPC: C07K14/725 ,  A61K35/17 ,  A61P35/00 ,  C07K14/705 ,  C12N5/0783

CPC classification number: C07K14/7051 ,  A61K35/17 ,  A61P35/00 ,  C07K14/70517 ,  C07K14/70575 ,  C12N5/0636 ,  C07K2319/02

Abstract: The disclosure provides a chimeric antigen receptor (CAR) polypeptide having an antigen binding domain comprising an extracellular lectin which specifically binds to glycoproteins expressed on the surface of target cells. Also provided herein are engineered lymphocytes expressing the CAR polypeptide, a nucleic acid molecule encoding the CAR polypeptide, and methods of treating cancer.

公开(公告)号：US10450355B2

公开(公告)日：2019-10-22

申请号：US15511554

申请日：2015-09-16

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： David M. Markovitz ,  Jeanne A. Stuckey ,  Daniel M. Boudreaux ,  Jennifer Meagher ,  Hashim Al-Hashimi ,  Loic Salmon

IPC: C07K14/42 ,  A61L31/16 ,  A61K38/16 ,  A61K38/17 ,  A61L31/04 ,  A61K9/00 ,  A61K38/00

Abstract: Provided herein are chemical compounds, methods for their discovery, and their therapeutic and research use. Further provided herein are antiviral and antimicrobial lectin compounds and methods of their use.