公开(公告)号：US20170313669A1

公开(公告)日：2017-11-02

申请号：US15520389

申请日：2015-10-27

Applicant: THE SCRIPPS RESEARCH INSTITUTE ,  THE UNIVERSITY OF CONNECTICUT

Inventor： Benjamin F. CRAVATT ,  Siddhesh S. KAMAT ,  William H. PARSONS ,  Amy R. HOWELL ,  Kaddy CAMARA ,  Amy ANDERSON

IPC: C07D305/12 ,  A61K31/337 ,  A61K31/365

CPC classification number: C07D305/12 ,  A61K31/337 ,  A61K31/365 ,  A61K2121/00 ,  C07D305/10 ,  C07D407/12

Abstract: Provided herein are lactone compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as inhibitors of serine hydrolases, such as ABHD16A. Furthermore, the subject compounds and compositions may be useful for the treatment of, for example, PHARC and other neuroinflammatory diseases.