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公开(公告)号：US10918695B2
公开(公告)日：2021-02-16
申请号：US16239280
申请日：2019-01-03
发明人： Deepak Sharma , Santosh Kumar Sandur , Maikho Thoh , Raghavendra Shridhar Patwardhan , Dharmendra K. Maurya , Rahul Checker , Vikram P. Gota , Jayakumar Sundarraj , Haldhar Dev Sarma , Subrata Chattopadhyay
摘要： A method of treatment of disease condition resulting from deficiency of hematopoietic stem and progenitor cells and/or epidermal stem cells in skin comprising: administering to the subject suffering from said disease conditions, an effective amount of Jack bean lectin or a pharmaceutically acceptable salt thereof for increasing the abundance of hematopoietic stem cells and progenitor cells in bone marrow and/or epidermal stem cells in skin in vivo. Method of treating said conditions in a subject involves administering a single injection of lectin in a dose range of 0.5-2.0 mg/kg body weight to mouse leading to 2.815 to 3.55 fold increase in the abundance of epidermal stem cells in skin and a dose range of 8.0-10.0 mg/Kg body weight to a mouse leading to 2.36 to 6.67-fold increase in the abundance of hematopoietic stem and progenitor cells in bone marrow.
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公开(公告)号：US20200215152A1
公开(公告)日：2020-07-09
申请号：US16239280
申请日：2019-01-03
发明人： Deepak Sharma , Santosh Kumar Sandur , Maikho Thoh , Raghavendra Shridhar Patwardhan , Dharmendra K. Maurya , Rahul Checker , Vikram P. Gota , Jayakumar Sundarraj , Haldhar Dev Sarma , Subrata Chattopadhyay
摘要： Use of Jack bean lectin or a pharmaceutically acceptable salt thereof for increasing the abundance of hematopoietic stem cells and progenitor cells in bone marrow and/or epidermal stem cells in skin in vivo and a method of treatment involving the said lectin at a specific dose to treat conditions due to depletion of stem cells. Method of treating said conditions in a subject by administering a single injection of lectin dose 0.5-2.0 mg/kg body weight to mouse for increasing the abundance of skin stem cells from 2.815±0.100% (mean±SEM) in control untreated mice to 8.097±0.938% and 9.993±0.542% in mice treated with lectin dose of 0.5 mg/kg body weight and 2 mg/kg body weight respectively; and a dose range 8.0-10 mg/kg body weight to mouse for increasing the abundance of hematopoietic stem cells in bone marrow from 0.293±0.043% (mean±SEM) in control untreated mice to 1.956±0.592% and 0.692±0.193% in mice treated with lectin dose of 8.0 mg/kg body weight and 10 mg/kg body weight respectively.
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