公开(公告)号：US11344121B2

公开(公告)日：2022-05-31

申请号：US16092820

申请日：2017-04-14

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： Mahua Choudhury

IPC: C12Q1/68 ,  A47B97/00 ,  A44B11/00 ,  F16M13/02

Abstract: The subject invention pertains to biomarkers for identifying a subject as having high risk of the development PE. The biomarkers presented herein include miRNAs, post-translational modification of histone proteins, amount, expression and/or activity of histone or DNA modifying enzymes and methylation of sites in the genomic DNA. In certain embodiments, increased miR-17, increased acetylation of H4 histone protein, decreased amount, expression and/or activity of HDACS mRNA or protein or increased methylation of DNA at the genomic site CYP19A1 in the blood, serum or plasma of a subject compared to that of a control subject is used to predict the development of PE in the subject. The invention also provides kits and reagents to conduct assays to quantify biomarkers described herein. The invention further provides the methods of treating and/or managing PE in a subject identified as having a high risk of the development of PE.

公开(公告)号：US11291750B2

公开(公告)日：2022-04-05

申请号：US16079466

申请日：2017-02-23

Applicant: THE TEXAS A & M UNIVERSITY SYSTEM

Inventor： Mahua Choudhury ,  Xiaofeng Kang ,  Allison R. Ficht

IPC: A61L31/14 ,  A61F6/04 ,  A61K31/352 ,  A61K9/00 ,  A61K9/127 ,  A61L31/04

Abstract: A hydrogel condom containing an antioxidant can provide increased sexual pleasure, thus improving usage and resulting in prevention of disease and prevention of unwanted pregnancies.