公开(公告)号：US20220402998A1

公开(公告)日：2022-12-22

申请号：US17772539

申请日：2020-10-30

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： WENSHE RAY LIU ,  WENYUE CAO

IPC: C07K14/725 ,  C07K14/705 ,  A61K35/17 ,  A61P35/00 ,  C12N9/50 ,  C07K16/28

Abstract: The subject invention pertains to a chimeric antigen receptor, a T cell comprising said CAR and methods of making and using said CAR and said T cell for the treatment of a cancer and/or an immune disease. In specific embodiments, the method comprises the use of T cells comprising CARs to target different antigens on target cells. In further specific embodiments, the CARs of the invention comprise NS3 protease domains and cleavage sites, which NS3 domains are inhibited by small molecule inhibitors for customized CAR-T cell therapy.