公开(公告)号：US11474098B2

公开(公告)日：2022-10-18

申请号：US16228433

申请日：2018-12-20

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Steven Marx ,  Alexander Kushnir ,  Lin Yang ,  Alex Katchman ,  Henry M. Colecraft

IPC分类号： G01N33/50 ,  A61P9/00 ,  G01N33/68 ,  A61K31/4422

摘要： The present invention provides, inter alia, methods for identifying a candidate agent that can treat or ameliorate the effects of a heart condition caused by the effects of abnormal beta-adrenergic receptor activation on calcium levels in cardiomyocytes in a subject. Compositions that include the candidate agents identified by the methods disclosed, and methods of treating or ameliorating the effects of a heart condition in a subject by administering to the subject the candidate agents identified by the methods disclosed, are also provided.

公开(公告)号：US20190250145A1

公开(公告)日：2019-08-15

申请号：US16228433

申请日：2018-12-20

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Steven Marx ,  Alexander Kushnir ,  Lin Yang ,  Alex Katchman ,  Henry M. Colecraft

IPC分类号： G01N33/50 ,  A61K31/4422 ,  A61P9/00

CPC分类号： G01N33/5041 ,  A61K31/4422 ,  A61P9/00

摘要： The present invention provides, inter alia, methods for identifying a candidate agent that can treat or ameliorate the effects of a heart condition caused by the effects of abnormal beta-adrenergic receptor activation on calcium levels in cardiomyocytes in a subject. Compositions that include the candidate agents identified by the methods disclosed, and methods of treating or ameliorating the effects of a heart condition in a subject by administering to the subject the candidate agents identified by the methods disclosed, are also provided.