公开(公告)号：US20230135464A1

公开(公告)日：2023-05-04

申请号：US17642592

申请日：2020-09-11

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Robert A. Cramer, Jr. ,  Caitlin Kowalski

IPC: C12N15/80 ,  C12N15/52 ,  C07K14/38

Abstract: Filamentous fungal host cells expressing hypoxia responsive morphology factor A (hrmA) and biofilm architecture factor (baf) proteins are provided. Methods of producing filamentous fungal host cells expressing hrmA and baf proteins are also provided. In one aspect, the disclosure provides a filamentous fungal host cell, comprising a nucleotide sequence encoding an Aspergillus fumigatus hypoxia responsive morphology factor A (hrmA) protein, or a homolog or ortholog thereof.

公开(公告)号：US12116579B2

公开(公告)日：2024-10-15

申请号：US17642592

申请日：2020-09-11

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Robert A. Cramer, Jr. ,  Caitlin Kowalski

IPC: C12N15/80 ,  C07K14/38 ,  C12N15/52

CPC classification number: C12N15/80 ,  C07K14/38 ,  C12N15/52

Abstract: Filamentous fungal host cells expressing hypoxia responsive morphology factor A (hrmA) and biofilm architecture factor (baf) proteins are provided. Methods of producing filamentous fungal host cells expressing hrmA and baf proteins are also provided. In one aspect, the disclosure provides a filamentous fungal host cell, comprising a nucleotide sequence encoding an Aspergillus fumigatus hypoxia responsive morphology factor A (hrmA) protein, or a homolog or ortholog thereof.

公开(公告)号：US20250034581A1

公开(公告)日：2025-01-30

申请号：US18440756

申请日：2024-02-13

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Robert A. Cramer, JR. ,  Caitlin Kowalski

IPC: C12N15/80 ,  C07K14/38 ,  C12N15/52

Abstract: Filamentous fungal host cells expressing hypoxia responsive morphology factor A (hrmA) and biofilm architecture factor (baf) proteins are provided. Methods of producing filamentous fungal host cells expressing hrmA and baf proteins are also provided.