公开(公告)号：US20240409643A1

公开(公告)日：2024-12-12

申请号：US18621312

申请日：2024-03-29

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： William G. NORTH

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

Abstract: The disclosure provides anti-NMDAR2B agents such as anti-NMDAR2B antibodies (Abs), antigen-binding Ab fragments, multi-specific Abs and antigen-binding Ab fragments, antibody-drug conjugates (ADCs), and chimeric antigen receptors (CARs). The disclosure also provides polynucleotides and vectors encoding, cells and pharmaceutical compositions comprising such anti-NMDAR2B agents and/or polynucleotides. The present disclosure further relates to methods of treating a subject using such anti-NMDAR2B agents and compositions, and to methods of treating, preventing, or diagnosing a disease such as cancer and methods of stimulating an immune response. Also provided are methods of producing such anti-NMDAR2B agents and cells.