公开(公告)号：US10590057B2

公开(公告)日：2020-03-17

申请号：US16060665

申请日：2016-12-14

Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY

Inventor： John T. Groves ,  Xinyi Chen

IPC: C07C17/10 ,  C07C17/12 ,  C07C17/14 ,  C07C45/63 ,  C07C67/287 ,  C07C253/30 ,  B01J31/22 ,  C07B59/00 ,  C07D209/48 ,  B01J31/32 ,  C07C67/307 ,  C07C231/12 ,  C07C269/06 ,  C07B39/00 ,  B01J31/18 ,  C07D209/50 ,  C07F13/00

Abstract: Methods of C—H bond fluorination using non-heme manganese catalyst are described herein. For example, a method comprises providing a reaction mixture including a non-heme manganese catalyst, a substrate comprising an sp3 C—H bond and a fluorinating agent and converting the sp3 C—H bond to a C—F bond in the presence of the non-heme manganese catalyst or a derivative thereof.