公开(公告)号：US20240374663A1

公开(公告)日：2024-11-14

申请号：US18690101

申请日：2022-10-12

Applicant: THE UAB RESEARCH FOUNDATION

Inventor： Gregory Friedman ,  James Markert ,  George Yancey Gillespie ,  Joshua Bernstock ,  Kyung-Don Kang

IPC: A61K35/763 ,  A61K9/00 ,  A61K31/713 ,  A61K38/21 ,  A61P35/00

Abstract: A method of treating a central nervous system cancer in a subject comprising administering to the subject a preconditioning agent, and, administering to the subject a therapeutic dose of an oncolytic virus; wherein the preconditioning agent is an immunostimulant selected from the group consisting of a toll-like receptor agonist, a subtherapeutic dose of an oncolytic virus, and/or an interferon that induces a transient anti-viral response and/or upregulates an interferon response; and wherein the preconditioning agent and the therapeutic dose of the oncolytic virus is administered to the subject's cerebrospinal fluid or periependymal region. Provided herein are methods of treating a central nervous system cancer in a subject. This method allows for intrathecal administration of oncolytic virus, which, until the present invention, resulted in unacceptable toxicity.