专利检索 ap:("THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC" OR "University of Kansas" OR "Northwestern University") AND inv:"Udo Rudloff" 第 1 页

1.

发明申请
FORMULATIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS 有权

公开(公告)号：US20210186972A1

公开(公告)日：2021-06-24

申请号：US17055256

申请日：2019-05-15

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC , University of Kansas , Northwestern University

发明人： Udo Rudloff , Serguei Kozlov , Juan Jose Marugan , Sui Huang , Samarjit Patnaik , John C. Braisted , Noel T. Southall , Marc Ferrer , Christopher Dextras , John Haslam , Michael Baltezor

IPC分类号： A61K31/519 , A61K47/12 , A61K45/06 , A61K31/7068 , A61P35/04

摘要： Disclosed are pharmaceutical formulations comprising a compound of formula (I): in which R1, R2, R3, and R4 are as described herein, or a pharmaceutically acceptable salt thereof. Also provided are methods for treating pancreatic adenocarcinoma comprising administration of a compound of formula (I), or a pharmaceutically acceptable salt thereof, and methods of detecting the change in expression levels of one or both of FoxA1 and FoxO6 in a pancreatic adenocarcinoma tumor sample from a mammal, wherein the mammal has been administered a compound of formula (I), or a pharmaceutically acceptable salt thereof.

2.

发明公开
FORMULATIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS 审中-公开

公开(公告)号：US20240316056A1

公开(公告)日：2024-09-26

申请号：US18735506

申请日：2024-06-06

申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services , University of Kansas , Northwestern University

发明人： Udo Rudloff , Serguei Kozlov , Juan Jose Marugan , Sui Huang , Samarjit Patnaik , John C. Braisted , Noel T. Southall , Marc Ferrer , Christopher Dextras , John Haslam , Michael Baltezor

IPC分类号： A61K31/519 , A61K31/7068 , A61K45/06 , A61K47/12 , A61P35/04

CPC分类号： A61K31/519 , A61K31/7068 , A61K45/06 , A61K47/12 , A61P35/04

摘要： Disclosed are pharmaceutical formulations comprising a compound of formula (I):

in which R1, R2, R3, and R4 are as described herein, or a pharmaceutically acceptable salt thereof. Also provided are methods for treating pancreatic adenocarcinoma comprising administration of a compound of formula (I), or a pharmaceutically acceptable salt thereof, and methods of detecting the change in expression levels of one or both of FoxA1 and FoxO6 in a pancreatic adenocarcinoma tumor sample from a mammal, wherein the mammal has been administered a compound of formula (I), or a pharmaceutically acceptable salt thereof.