专利检索 ap:("THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES" OR "THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL") AND inv:"Xin HU" 第 1 页

1.

发明公开
D3 DOPAMINE RECEPTOR-SELECTIVE NEGATIVE ALLOSTERIC MODULATORS 审中-公开

公开(公告)号：US20240336604A1

公开(公告)日：2024-10-10

申请号：US18294663

申请日：2022-08-03

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES , THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

发明人： Disha GANDHI , Kevin FRANKOWSKI , Marc FERRER , R. Benjamin FREE , David R. SIBLEY , Amy E. MORITZ , Noel Terrence SOUTHALL , Xin HU , Amber KELLEY

IPC分类号： C07D413/06 , A61K31/4025 , A61K31/424 , A61K31/426 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D207/416 , C07D277/14 , C07D401/06 , C07D403/06 , C07D498/10

CPC分类号： C07D413/06 , A61K31/4025 , A61K31/424 , A61K31/426 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D207/416 , C07D277/14 , C07D401/06 , C07D403/06 , C07D498/10

摘要： Compounds of Formula I, Formula II, and Formula III and the pharmaceutically acceptable salts thereof are disclosed. The variables R1-10 are disclosed herein. The compounds are useful for treating central nervous system disorders, especially those involving substance use disorder and/or withdrawal syndrome. Pharmaceutical compositions containing compounds of Formula I or Formula II or Formula III and methods of treatment comprising administering compounds of Formula I or Formula II or Formula III are also disclosed.