公开(公告)号：US20250127814A1

公开(公告)日：2025-04-24

申请号：US18695701

申请日：2022-10-06

Applicant: THE UNIVERSITY OF CHICAGO

Inventor： Anthony KOSSIAKOFF ,  Annika SÄÄF ,  Marcin URA ,  Somnath MUKHERJEE

IPC: A61K35/17 ,  A61K40/11 ,  A61K40/15 ,  A61K40/31 ,  A61K40/42 ,  A61K45/06 ,  A61P35/00 ,  C07K16/28 ,  C12N5/0783 ,  C12N15/85 ,  G01N33/573 ,  G01N33/58

Abstract: Aspects of the present disclosure are directed to borealin-targeting polypeptides, including antibodies, antibody-drug conjugates, antibody fragments, antibody-like molecules, and chimeric receptors. Also disclosed herein are nucleic acids encoding for such borealin-targeting polypeptides and cells comprising such nucleic acids. Described are methods for detection, diagnosis, and treatment of cancer using borealin-targeting polypeptides.

公开(公告)号：US20240408138A1

公开(公告)日：2024-12-12

申请号：US18697566

申请日：2022-10-06

Applicant: THE UNIVERSITY OF CHICAGO

Inventor： Anthony KOSSIAKOFF ,  Annika SÄÄF ,  Marcin URA ,  Somnath MUKHERJEE

IPC: A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K16/28 ,  C12N5/0783 ,  G01N33/543 ,  G01N33/574

Abstract: Aspects of the present disclosure are directed to INCENP-targeting polypeptides, including antibodies, antibody-drug conjugates, antibody fragments, antibody-like molecules, and chimeric receptors. Also disclosed herein are nucleic acids encoding for such INCENP-targeting polypeptides and cells comprising such nucleic acids. Described are methods for detection, diagnosis, and treatment of cancer using INCENP-targeting polypeptides.

公开(公告)号：US20250018038A1

公开(公告)日：2025-01-16

申请号：US18695590

申请日：2022-10-06

Applicant: THE UNIVERSITY OF CHICAGO

Inventor： Anthony KOSSIAKOFF ,  Annika SÄÄF ,  Marcin URA ,  Somnath MUKHERJEE

IPC: A61K39/00 ,  C07K14/725 ,  C07K16/18 ,  G01N33/574

Abstract: Aspects of the present disclosure are directed to survivin-targeting polypeptides, including antibodies, antibody-drug conjugates, antibody fragments, antibody-like molecules, and chimeric receptors. Also disclosed herein are nucleic acids encoding for such survivin-targeting polypeptides and cells comprising such nucleic acids. Described are methods for detection, diagnosis, and treatment of cancer using survivin-targeting polypeptides.