公开(公告)号：US20190314554A1

公开(公告)日：2019-10-17

申请号：US16428534

申请日：2019-05-31

Applicant: THE UNIVERSITY OF KANSAS

Inventor： Michael DETAMORE ,  Emily BECK ,  Stevin GEHRKE ,  Cory BERKLAND

IPC: A61L27/48 ,  A61L27/38 ,  A61L27/50 ,  A61L27/20 ,  A61L27/52 ,  A61L27/54

Abstract: An implantable hydrogel precursor composition can include: a cross-linkable polymer matrix that is biocompatible; and a plurality of polymer particles in the cross-linkable polymer matrix. The cross-linkable polymer matrix can include a cross-linkable hyaluronic acid polymer that has cross-linkable functional groups. The hyaluronic acid polymer can be a methacrylated hyaluronic acid polymer. The methacrylated hyaluronic acid polymer can have a molecular weight from about 500 kDa to about 1.8 MDa. The polymer particles can include a cross-linked hyaluronic acid. The cross-linkable polymer matrix having the polymer particles has a yield stress. The cross-linkable polymer matrix having the polymer particles has shape retention at physiological temperatures. The composition can include live cells in the cross-linkable polymer matrix. The composition can include a biologically active agent in the cross-linkable polymer matrix.