专利检索 ap:("THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION") AND inv:"Rukhsana Awais" 第 1 页

1.

发明授权
Controlling biofilms with cyclopropanated fatty acids 有权

公开(公告)号：US11311506B2

公开(公告)日：2022-04-26

申请号：US16670802

申请日：2019-10-31

申请人： THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION

发明人： Jessica Amber Jennings , Daniel Lee Baker , Rukhsana Awais , Zoe Harrison , Babatunde Raji

IPC分类号： A61K31/19 , A61P1/02 , A01N37/08 , A61K47/36 , A61P31/04

摘要： Compositions and methods for using cyclopropanated structural analogs of fatty acid biofilm dispersal agents are characterized by superior biofilm dispersion. When used in combination with antimicrobials, these analogs decrease the minimum inhibitory concentration of antimicrobial agents required for eradication of the biofilm and/or treatment of infection. Methods for using these analogs include direct application to a surface, blending with lipid based carriers, or covalent anchoring the molecule to a surface. Typically, the cyclopropanated structural analog has the structure according to formula (I): wherein R1 is a C1-C24 linear or branched alkyl group; or an acid halide or acid anhydride thereof.