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公开(公告)号：US20220169581A1
公开(公告)日：2022-06-02
申请号：US17434677
申请日：2020-02-27
发明人： Zibo Li , David Nicewicz , Wei Chen
IPC分类号： C07B59/00 , B01J35/00 , B01J31/00 , C07C41/22 , C07C17/12 , C07C253/30 , C07C45/63 , C07C67/307 , C07C231/12 , C07C269/06 , C07D239/96 , C07D213/69 , C07D215/20 , C07D231/56 , C07D235/24 , C07D263/58 , C07D311/22
摘要： The invention generally relates to methods of making substituted arenes via direct C—H, C—O, C—S, or C—N bond conversion and methods of synthesizing isotopically-labeled substituted arenes via direct carbon-halogen bond conversion. The invention also relates to anaerobic catalyst systems comprising an acridinium photocatalyst and a nucleophile selected from a halide, a cyanide, and an isotopically-labeled amine. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20220096539A1
公开(公告)日：2022-03-31
申请号：US17424109
申请日：2020-01-17
申请人： University of Georgia Research Foundation, Inc. , The University of North Carolina at Chapel Hill
发明人： Jin Xie , Wen Jiang , Trever Todd , Zibo Li
摘要： Particles formed from an alkai metal or alkaline earth metal and halide, for example, sodium and chloride, are provided. The particles can have a hydrophilic coating or external layer, formed of, for example, a polyether-lipid conjugate. In preferred embodiments, the lipid is a phospholipid such as a phosphoethanolamine, and the polyether is a polyethylene glycol such as a PEG amine. Methods making the particles by, for example, a microemulsion reaction, are also provided. Pharmaceutical compositions including a plurality of particles and a pharmaceutically acceptable carrier are also disclosed. Typically the compositions include an effective amount of particles to treat a disease or condition, particularly cancer, in a subject in need thereof. The particles are typically nanoparticles, for example, between about 10 nm and 250 nm and can be monodisperse.
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公开(公告)号：US11103603B2
公开(公告)日：2021-08-31
申请号：US16343267
申请日：2017-10-20
发明人： Zibo Li , Zhanhong Wu , Ben Giglio , Stergios Moschos
摘要： The present invention relates to 18F-labeled compounds suitable for positron emission tomography (PET) imaging. The invention further relates to the use of these compounds for carrying out PET scans, imaging the indoleamine 2,3-dioxygenase, pathway, predicting the responsiveness of a subject with a solid tumor to therapies including immunotherapy such as PD-1/PD-L1 inhibition, and determining whether a solid tumor in a subject contains tumor-infiltrating immune cells.
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公开(公告)号：US20190247527A1
公开(公告)日：2019-08-15
申请号：US16343267
申请日：2017-10-20
发明人： Zibo Li , Zhanhong Wu , Ben Giglio , Stergios Moschos
CPC分类号： A61K51/0406 , A61K2123/00 , A61P35/00 , C07B59/002 , C07B2200/05
摘要： The present invention relates to 18F-labeled compounds suitable for positron emission tomography (PET) imaging. The invention further relates to the use of these compounds for carrying out PET scans, imaging the indoleamine 2,3-dioxygenase, pathway, predicting the responsiveness of a subject with a solid tumor to therapies including immunotherapy such as PD-1/PD-L1 inhibition, and determining whether a solid tumor in a subject contains tumor-infiltrating immune cells.
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