公开(公告)号：US20200024639A1

公开(公告)日：2020-01-23

申请号：US16486408

申请日：2018-02-14

Applicant: THE UNIVERSITY OF SHEFFIELD

Inventor： Bazbek Davletov ,  Andrew Alexander Peden ,  Aleksander Mikael Rudolf Rust ,  Ciara Louise Doran

IPC: C12Q1/66 ,  C07K14/705 ,  C12Q1/37

Abstract: The present invention provides a polypeptide comprising an N-terminal polypeptide domain having luciferase activity and a C-terminal polypeptide domain having VAMP1, VAMP2 or VAMP3 activity where VAMP stands for vesicle-associated membrane protein. Corresponding nucleic acid molecules, expression vectors and genetically modified cells are also provided. The invention also provides methods and uses of the same.

公开(公告)号：US11345945B2

公开(公告)日：2022-05-31

申请号：US16486408

申请日：2018-02-14

Applicant: THE UNIVERSITY OF SHEFFIELD

Inventor： Bazbek Davletov ,  Andrew Alexander Peden ,  Aleksander Mikael Rudolf Rust ,  Ciara Louise Doran

IPC: C12Q1/66 ,  C07K14/705 ,  C12Q1/37

Abstract: The present invention provides a polypeptide comprising an N-terminal polypeptide domain having luciferase activity and a C-terminal polypeptide domain having VAMP1, VAMP2 or VAMP3 activity where VAMP stands for vesicle-associated membrane protein. Corresponding nucleic acid molecules, expression vectors and genetically modified cells are also provided. The invention also provides methods and uses of the same.